Publications (2004 to 2008)

1. Ye, H, Yu, T, Temam, S, Ziober, B L, Wang, J, Schwartz, J L, Mao, L, Wong, D T, and Zhou, X Transcriptomic dissection of tongue squamous cell carcinoma. BMC genomics, 2008; 9: 69.
   
   
2. Tan, W, Sabet, L, Li, Y, Yu, T, Klokkevold, P R, Wong, D T, and Ho, C M Optical protein sensor for detecting cancer markers in saliva. Biosens Bioelectron, 2008.
   
   
3. Hu, Z, Zimmermann, B G, Zhou, H, Wang, J, Henson, B S, Yu, W, Elashoff, D, Krupp, G, and Wong, D T Exon-Level Expression Profiling: A Comprehensive Transcriptome Analysis for Oral Fluids. Clin Chem, 2008, 54: 824-832.
   
   
4. Denny, P, Hagen, F K, Hardt, M, Liao, L, Yan, W, Arellanno, M, Bassilian, S, Bedi, G S, Boontheung, P, Cociorva, D, Delahunty, C M, Denny, T, Dunsmore, J, Faull, K F, Gilligan, J, Gonzalez-Begne, M, Halgand, F, Hall, S C, Han, X, Henson, B, Hewel, J, Hu, S, Jeffrey, S, Jiang, J, Loo, J A, Ogorzalek Loo, R R, Malamud, D, Melvin, J E, Miroshnychenko, O, Navazesh, M, Niles, R, Park, S K, Prakobphol, A, Ramachandran, P, Richert, M, Robinson, S, Sondej, M, Souda, P, Sullivan, M A, Takashima, J, Than, S, Wang, J, Whitelegge, J P, Witkowska, H E, Wolinsky, L, Xie, Y, Xu, T, Yu, W, Ytterberg, J, Wong, D T, Yates, J R, 3rd, and Fisher, S J The Proteomes of Human Parotid and Submandibular/Sublingual Gland Salivas Collected as the Ductal Secretions. J Proteome Res, 2008; 7: 1994-2006.
   
   
5. Segal, A and Wong, D T Salivary diagnostics: enhancing disease detection and making medicine better. Eur J Dent Educ, 2008; 12 Suppl 1: 22-29.
   
   
6. Deshpande, A M and Wong, D T Molecular mechanisms of head and neck cancer. Expert review of anticancer therapy, 2008; 8: 799-809.
   
   
7. Wei, F, Wang, J, Liao, W, Zimmermann, B G, Wong, D T, and Ho, C M Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe. Nucleic acids research, 2008.
   
   
8. Koka, S, Beebe, T J, Merry, S P, Dejesus, R S, Berlanga, L D, Weaver, A L, Montori, V M, and Wong, D T The preferences of adult outpatients in medical or dental care settings for giving saliva, urine or blood for clinical testing. J Am Dent Assoc, 2008; 139: 735-740.
   
   
9. Srivastava, A., J. Wang, H. Zhou, J. E. Melvin, and D. T. Wong. 2008. Age and gender related differences in human parotid gland gene expression. Arch Oral Biol., 2008: in press.
   
   
10. Hu, S, Arellano, M, Boontheung, P, Wang, J, Zhou, H, Elashoff, D, Loo, J A, and Wong, D T Salivary Proteomics for Oral Cancer Biomarker Discovery. Clin Cancer Res, 2008: in press.
    
    
11. Wong, D T Saliva Diagnostics. American Scientist, 2008; 96: 37-43.
    
    
12. Wong, D.T. (editor) (2008) Saliva Diagnostics. Blackwell Publisher.
    
    
13. Gau, V and Wong, D Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform. Ann N Y Acad Sci, 2007; 1098: 401-410.
    
    
14. Whitelegge, J, Zabrouskov, V, Halgrand, F, Souda, P, Bassilian, S, Yan, W, Wolinsky, L, Loo, J A, Wong, D T, and Faull, K Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top-down Fourier-transform ion cyclotron resonance mass spectrometry. International Journal of Mass Spectrometry, 2007; 268: 190-197.
    
    
15. Zimmermann, B G and Wong, D T Salivary mRNA targets for cancer diagnostics. Oral Oncol, 2007.
    
    
16. Park, N J, Zhou, X, Yu, T, Brinkman, B M, Zimmermann, B G, Palanisamy, V, and Wong, D Characterization of salivary RNA by cDNA library analysis. Arch Oral Biol, 2007; 52: 30-35.
    
    
17. Peng, H, Shintani, S, Kim, Y, and Wong, D T. Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor ß-Smad signaling pathway Neoplasia, 2007; 8: 1028-1036.
    
    
18. Gau, V and Wong, D Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform. Ann N Y Acad Sci, 2007; 1098: 401-410.
    
    
19. Hu, S, Loo, J A, and Wong, D T Human saliva proteome analysis. Ann N Y Acad Sci, 2007; 1098: 323-329.
    
    
20. Wong, D T Salivary transcriptome. Clin Cancer Res, 2007; 13: 1350-1351; author reply 1351.
    
    
21. Zimmermann, B G, Park, N J, and Wong, D T Genomic targets in saliva. Ann N Y Acad Sci, 2007; 1098: 184-191.
    
    
22. Ye, H, Pungpravat, N, Huang, B L, Muzio, L L, Mariggio, M A, Chen, Z, Wong, D T, and Zhou, X Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma. Cancer Genetics and Cytogenetics, 2007; 176: 100-106.
    
    
23. Yu, T, Ye, H, Sun, W, Li, K C, Chen, Z, Jacobs, S, Bailey, D K, Wong, D T, and Zhou, X A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics, 2007; 8: 145.
    
    
24. Molinolo, A A, Hewitt, S M, Amornphimoltham, P, Keelawat, S, Rangdaeng, S, Meneses Garcia, A, Raimondi, A R, Jufe, R, Itoiz, M, Gao, Y, Saranath, D, Kaleebi, G S, Yoo, G H, Leak, L, Myers, E M, Shintani, S, Wong, D, Massey, H D, Yeudall, W A, Lonardo, F, Ensley, J, and Gutkind, J S Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res, 2007; 13: 4964-4973.
    
    
25. Hu, S, Loo, J A, and Wong, D T Human saliva proteome analysis and disease biomarker discovery. Expert Rev Proteomics, 2007; 4: 531-538.
    
    
26. Hu, S, Wang, J, Meijer, J, Ieong, S, Xie, Y, Yu, T, Zhou, H, Henry, S, Vissink, A, Pijpe, J, Kallenberg, C, Elashoff, D, Loo, J A, and Wong, D T Salivary proteomic and genomic biomarkers for primary Sjogren's syndrome. Arthritis and Rheumatism, 2007; 56: 3588-3600.
    
    
27. Hu, S and Wong, D T Oral cancer proteomics. Current opinion in molecular therapeutics, 2007; 9: 467-476.
    
    
28. Hu, S, Yen, Y, Ann, D, and Wong, D T Implications of salivary proteomics for cancer drug discovery. Drug Discovery, 2007; 12: 911-916.
    
    
29. Hu, S, Yu, T, Xie, Y, Yang, Y, Li, Y, Zhou, X, Tsung, S, Loo, R R, Loo, J R, and Wong, D T Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry. Cancer Genomics Proteomics, 2007; 4: 55-64.
    
    
30. Zhou, X and Wong, D T Single nucleotide polymorphism mapping array assay. Methods Mol Biol, 2007; 396: 295-314.
    
    
31. Hu, S, Loo, J A L, and Wong, D T W Human body fluid proteome analysis. Proteomics, 2006; 6: 6326-6353.
    
    
32. Hu, S, Li, Y, Xie, Y, Tjon, K, Loo, R R, Loo, J A L, and Wong, D T. Human Saliva Proteome and Transcriptome. J. Dent. Res., 2006; 85: 1129-1133.
    
    
33. Park, N J, Yu, T, Nabili, V, Brinkman, B M, Henry, S, Wang, J, and Wong, D T RNAprotect Saliva: An Optimal Room- Temperature Stabilization Reagent for the Salivary Transcriptome. Clin Chem, 2006; 52: 2303-2304.
    
    
34. Zhou, X, Temam, S, Oh, M, Pungpravat, N, Huang, B-L, Mao, L, and Wong, D T. Global expression based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma. Neoplasia, 2006:8(11):925-932
    
    
35. Kwong, J, Lee, J Y, Wong, K K, Zhou, X, Wong, D T, Lo, K W, Welch, W R, Berkowitz, R S, and Mok, S C Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer. Neoplasia, 2006; 8: 268-278.
    
    
36. Gu, F, Li, Y, Zhou, X, Wong, D T, Ho, C M, Shi, W, and Qi, F Bacterial 16S RNA/DNA Profiling in the Liquid Phase of the Saliva. Oral Microbiology and Immunology, 2006: in press.
    
    
37. Wong, D T. Towards a simple, saliva-based test for the detection of oral cancer 'oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance'. Expert Rev Mol Diagn, 2006; 6: 267-272.
    
    
38. Park, N J, Li, Y, Yu, T, Brinkman, B M, and Wong, D T. Characterization of RNA in saliva. Clin Chem, 2006; 52: 988-994.
    
    
39. Ramachandran, P, Boontheung, P, Xie, Y, Sondej, M, Wong, D T, and Loo, J A Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J Proteome Res, 2006; 5: 1493-1503.
    
    
40. Wong, D T Salivary Diagnostics for Oral Cancer. J. California Dent. Assoc., 2006; 34: 303-308.
    
    
41. Nguyen, S and Wong, D T Cultural, Behavorial, Social, and Psychological Perception of Saliva: Relevance to Clinical Diagnostics. J. California Dent. Assoc., 2006; 34: 317-322.
    
    
42. Wong, D T. Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J American Dental Association, 2006; 137: 313-321.
    
    
43. Brinkman, B M and Wong, D T. Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol, 2006; 18: 228-233.
    
    
44. St John, M A, Abemayor, E and Wong, D T. Recent new approaches to the treatment of head and neck cancer. Anti-Cancer Drugs, 2006; 17: 365-375.
    
    
45. Figueiredo, M L, Dayan, S, Kim, Y, McBride, J, Kupper, T S, and Wong, D T Expression of cell-cycle regulator CDK2-associating protein 1 (p12(CDK2AP1)) in transgenic mice induces testicular and ovarian atrophy in vivo. Mol Reprod Dev, 2006; 73: 987-997.
    
    
46. Li, Y, Elashoff, D, Oh, M, Sinha, U, St John, M A, Zhou, X, Abemayor, E, and Wong, D T Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol, 2006; 24: 1754-1760.
    
    
47. Forde, M D, Koka, S, Eckert, S E, Carr, A B, and Wong, D T Systemic assessments utilizing saliva: part 1 general considerations and current assessments. Int J Prosthodont, 2006; 19: 43-52.
    
    
48. Zhou, X, Yu, T, Cole, S and Wong, D T. Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer. Expert Rev Mol Diagn, 2006; 6: 39-50.
    
    
49. Zhou, X, Temam, S, Chen, Z, Ye, H, Mao, L and Wong, D T. Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA. Hum Genet, 2005: 1-4.
    
    
50. Zhou, X, Jordan, R C, Li, Y, Huang, B L, and Wong, D T. Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions. Cancer Genet Cytogenet, 2005; 161: 86-89.
    
    
51. Yang, C Y, Brooks, E, Li, Y, Denny, P, Ho, C M, Qi, F, Shi, W, Wolinsky, L, Wu, B, Wong, D T and Montemagno, C D Detection of picomolar levels of interleukin-8 in human saliva by SPR. Lab Chip, 2005; 5: 1017-1023.
    
    
52. Li, Y, Denny, P, Ho, C M, Montemagno, C, Shi, W, Qi, F, Wu, B, Wolinsky, L, and Wong, D T. The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications. Adv Dent Res, 2005; 18: 3-5.
    
    
53. Kim, Y, Ohyama, H, Patel, V, Figueiredo, M L, and Wong, D T. Mutation of Cys10 105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. J Biol Chem, 2005; 280: 23273-23279.
    
    
54. Figueiredo, M L, Kim, Y, St John, M A, and Wong, D T. p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer. Clin Cancer Res, 2005; 11: 3939-3948.
    
    
55. Gu, F, Lux, R, Du-Thumm, L, Stokes, I, Kreth, J, Anderson, M H, Wong, D T, Wolinsky, L, Sullivan, R, and Shi, W In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies. J Microbiol Methods, 2005; 62: 145-160.
    
    
56. Hu, S, Xie, Y, Ramachandran, P, Loo, R R, Li, Y, Loo, J A, and Wong, D T. Large-Scale Identification of Human Oral Fluid Proteins by Liquid Chromatography-Mass Spectrometry. Proteomics, 2005, 5: 1714-1728.
    
    
57. Zhou, X, Egusa, H, Cole, S W, Nishimura, I, and Wong, D T W Methodology of microarray data analysis. In: M. A. Hayat (ed.), Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas (Molecular Genetics, Liver Carcinoma and Pancreatic Cancer), Vol. 3, pp. in press, 2005.
    
    
58. Kim, Y, McBride, J, Zhang, R, Zhou, X, and Wong, D T. p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin. Oncogene, 2005; 24: 407-418.
    
    
59. Zhou, X, Rao, N P, Cole, S W, Mok, S C, Cheng, Z, and Wong, D T. Progress in concurrent progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genetics & Cytogenetics, 2005, 159: 53-57.
    
    
60. Zhou, X, Cole, S W, Rao, N P, Cheng, Z, Li, Y L, McBride, J, and Wong, D T W. Identification of discrete chromosomal deletion by binary recursive partitioning of microarray differential expression data. J. Med Genetics, 2005, 42: 416-419.
    
    
61. Kim, Y, Shintani, S, Yohko, K, Zhang, R, and Wong, D T. Cyclin G2 dysregulation in human oral cancer. Cancer Research., 2004, 64: 8980-8906.
    
    
62. Kreth, J K, Hagerman, E, Tam, K, Merritt, J, Wong, D, Wu, B M, Myung, N V, Shi, W, and Qi, F Quantitative Analyses of Streptococcus mutans Biofilms Formed under Different Sucrose Concentrations by using quartz crystal microbalance and microjet impingement. Biofilm, 2004; 1: 277-284.
    
    
63. Figueiredo, M L, Kim, Y K, Zhou, X Z, Myers, J N, and Wong, D T. Molecular Mechanisms of Head and Neck Cancer. Mechanism of Diseases, 2004, 1: 273-281.
    
    
64. Li, Y, St John, M A, Zhou, X, Kim, Y, Sinha, U, Jordan, R C K, Eisele, D, Abemayor, E, Elashoff, D, Park, N H, and Wong, D T Salivary Transcriptome Diagnostics for Oral Cancer Detection. Clin Cancer Res, 2004; 10: 8442-8450.
    
    
65. Jordan, R C K, Macabeo, M, Shiboski, C H, Dekker, N, Ginzinger, D, Wong, D T, and Schmidt, B L. Overexpression of matrix metalloproteinases-1 and 9 mRNA are associated with progression of oral dysplasia to cancer. Clin Cancer Res, 2004: 6460-6465.
    
    
66. Hu, S, Denny, P, Denny, P A, Xie, Y, Loo, J A, Wolinsky, L, Li, Y, McBride, J, Loo, R R, Navazesh, M, and Wong, D T Differentially expressed proteins markers in human submandibular and sublingual secretions. Int. J. Oncol., 2004; 25: 1423-1430.
    
    
67. Zhou, X, Mok, S, Li, C, Chen, Z, and Wong, D T Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using Affymetrix 10K SNP mapping array. Human Genetics, 2004; 115: 327-330..
    
    
68. Shintani, S, Ishikawa, T, Nonaka, T, Li, C, Nakashiro, K, Wong, D T, and Hamakawa, H. Growth-regulated oncogene-1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer. Oncology, 2004; 66: 316-322.
    
    
69. Buajeeb, W, Zhang, X, Ohyam, H, Han, D, Surarita, R, Kim, Y, and Wong, D T. Interaction of the CDK2 associated protein-1, p12DOC-1/CDK2AP1, with its homolog, p14DOC-1R. Biochem Biophys Res Comm, 2004; 315: 998-1003.
    
    
70. Li, Y, Zhou, X, St John, M A, and Wong, D T. RNA Profiling of Cell-free Saliva Using Microarray Technology. J Dent Res, 2004; 83: 199-203.
    
    
71. St. John, M, Li, Y, Zhou, X, Denny, P, Ho, C-M, Montemagno, C D, Shi, W, Qi, F, Wu, B, Jordan, R C K, Sinha, U, Park, N-H, Abemayor, E, and Wong, D T W IL-6 and IL-8: Potential biomarkers for oral cavity and oropharyngeal SCCA. Arch Otolaryngol Head Neck Surg, 2004, 130: 929-935.
    
    
72. Zhou, X, Li, C, Mok, S, Chen, Z, and Wong, D T W Whole Genome LOH Profiling on Oral Squamous Cell Carcinoma by High-Density SNP Array. Cancer Genet & Cytogenet, 2004; 151: 82-84.
    
    
73. Hu, M G, Hu, G F, Kim, Y, Tsuji, T, McBride, J, Hinds, P, and Wong, D T Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression. Cancer Res, 2004; 64: 490-499.
    
    
74. Zhou, X, Jordan, R C K, Mok, S, Birrer, M J, and Wong, D T DNA Copy Number Abnormality of Oral Squamous Cell Carcinoma Detected by cDNA Array-Based CGH. Cancer Genetics & Cytogenetics, 2004; 151: 90-92.
    
    
75. Zhou, X., Cole, S. W., Hu, S., and Wong, D. T. Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet, 2004; 114: 464-467.